Hageman Factor Deficiency

Important
It is possible that the main title of the report Hageman Factor Deficiency is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

Factor XII Deficiency
HAF Deficiency
Hageman Trait

Disorder Subdivisions

None

General Discussion

Hageman factor deficiency, also known as factor XII deficiency, is a rare genetic blood disorder that causes prolonged clotting (coagulation) of blood in a test tube without the presence of prolonged clinical bleeding tendencies. It is caused by a deficiency of the Hageman factor (factor XII), a plasma protein (glycoprotein). Although it is thought that factor XII is needed for blood clotting, when it is deficient, other blood clotting factors tend to compensate for its absence. This disorder is thought to be benign and usually presents no symptoms (asymptomatic); it is usually only accidentally discovered through pre-operative blood tests that are required by hospitals. Of substantial recent interest is the role of antibodies to Factor XII in recurrent pregnancy losses.
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Resources

National Hemophilia Foundation
116 West 32nd Street
11th Floor
New York, NY 10001
USA
Tel: (212)328-3737
Fax: (212)328-3795
Tel: (800)424-2634
Email: gwidlundDhemophilia.org
Internet: http://www.hemophilia.org

Canadian Hemophilia Society
625 President Kennedy
Suite 505
Montreal
Quebec, H3A 1K2
Canada
Tel: 5148480503
Fax: 5148489661
Tel: 8006682686
Email: chs@hemophilia.ca
Internet: http://www.hemophilia.ca

NIH/National Heart, Lung and Blood Institute Information Center
P.O. Box 30105
Bethesda, MD 20824-0105
Tel: (301)592-8573
Fax: (301)251-1223
Email: nhlbiinfo@rover.nhlbi.nih.gov

For a Complete Report

This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated: 3/11/2008
Copyright 1988, 1989, 2002, 2008 National Organization for Rare Disorders, Inc.

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